Symbol
Name
ID

Vegfa
vascular endothelial growth factor A
MGI:103178

Phenotype annotations related to renal/urinary system

Darker colors indicate more annotations

Human Phenotypes	Proteinuria	Renovascular hypertension	Abnormality of the bladder	Abnormality of the kidney	Nephrocalcinosis	Nephropathy	Nephrotic syndrome	Renal insufficiency	Acute kidney injury	Chronic kidney disease
Disease(s) Associated with VEGFA	Proteinuria	Renovascular hypertension	Abnormality of the bladder	Abnormality of the kidney	Nephrocalcinosis	Nephropathy	Nephrotic syndrome	Renal insufficiency	Acute kidney injury	Chronic kidney disease
multiple myeloma
pre-eclampsia
pseudoxanthoma elasticum

Mouse Phenotypes

abnormal kidney arterial blood vessel morphology

abnormal kidney afferent arteriole morphology

abnormal kidney interlobular artery morphology

abnormal kidney efferent arteriole morphology

abnormal glomerular capillary endothelium morphology

absent glomerular endothelium fenestra

abnormal glomerular capillary morphology

decreased glomerular capillary number

dilated glomerular capillary

abnormal peritubular capillary morphology

abnormal kidney vasculature morphology

kidney hemorrhage

abnormal mesangial cell morphology

detached podocyte

decreased urine creatinine level

increased urine protein level

albuminuria

abnormal kidney morphology

increased glomerular capsule space

abnormal podocyte morphology

podocyte foot process effacement

abnormal podocyte slit diaphragm morphology

abnormal renal glomerulus basement membrane morphology

abnormal renal glomerulus basement membrane thickness

increased renal glomerulus basement membrane thickness

abnormal renal glomerulus morphology

abnormal glomerular filtration barrier morphology

expanded mesangial matrix

mesangiolysis

cortical renal glomerulopathies

glomerulosclerosis

decreased renal glomerulus number

renal glomerulus atrophy

renal glomerulus hypertrophy

abnormal nephrogenic zone morphology

small kidney

kidney atrophy

abnormal loop of Henle morphology

abnormal proximal convoluted tubule morphology

dilated proximal convoluted tubule

dilated renal tubule

renal cast

pale kidney

decreased renal glomerular filtration rate

kidney failure

renal ischemia

Availability

Mouse Genotype

Vegfa^tm1Pec/Vegfa^tm1Pec

Tg(Neph1-Vegfa)1Seq/0

Tg(NPHS2-rtTA2*M2)1Jbk/0
Tg(tetO-RNAi:Vegfa)#Atuf/0

Vegfa^tm2Gne/Vegfa^tm2Gne
Tg(Nphs1-cre)1Seq/0 (conditional)

Vegfa^tm2Gne/Vegfa⁺
Tg(Nphs1-cre)1Seq/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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